I think Avanti West Coast services should continue north of Manchester Piccadilly post NPR and HS2 and be combined with the Transpennine Express Manchester Airport to Scotland service(dropping the Ringway stop bar 1tpd for route knowledge)
So my calling pattern
London Euston, Watford Junction, Milton Keynes Central, Northampton, Rugby, Coventry, B'ham Intl, B'ham New St, Sandwell and Dudley, Wolverhampton, Stafford, Stoke-on-Trent, Congleton(1tp2h), Macclesfield, Stockport, Manchester Piccadilly, Manchester Oxford Road, Deansgate(1tp2h), Wigan North Western, Preston, Lancaster, Oxenholme Lake District(1tp2h), Penrith North Lakes(1tp2h), Carlisle then alternate to Glasgow and Edinburgh
Glasgow Central portion
Motherwell, Glasgow Central
Edinburgh Waverley
Edinburgh Haymarket, Edinburgh Waverley
Diversion of 1tpd via Crewe, Airport, Bolton and Chorley
Calling pattern
Crewe, Wilmslow, Manchester Airport, East Didsbury, Manchester Piccadilly, Manchester Oxford Road, Deansgate, Salford Crescent, Bolton, Chorley , Preston and then as above