As I don't know what the 319s' reliability is faring on the NW electric lines, I'm not quite sure how to interpret your comment. I know that they were troublesome when they were first introduced, but much of the trouble was put down to the maintainers hitting a learning curve with their 'quirks'. It seems that their reliability has improved sufficiently for them not to get regular criticism, so I assume that the support teams have now got the gist of them.
So, back to the prognosis of their future performance, especially as class769s, - on diagrams with both electric and diesel mileage, (say 50% each), I would imagine that the electrics would get an easier time away from OLE than under it. That would be because the diesel genset is limited to a maximum power well below the continuous rating of the traction motors, and of course the transformer/rectifier/pantograph would be unused for that time. When powered by diesel, the engine and generator would be much newer than the rest of the equipment so their reliability should be no worse than that on a new train.
As far as the additional weight of the genset is concerned, this has been discussed more than once in this thread in that their combined weight (i.e. two per 4-car set) is similar to a full passenger load, which the units were no stranger to over much of their 30 years in Thqamelink use. Furthermore, those loads were regularly carried for 30-50 miles, which is the equivalent of trains full loaded including standing passengers, all the way from Lime St and Piccadilly, - something that I don't believe happens except maybe in times of severe disruption.