Not at all, I'm sure the OP would be happy for the local insight. As an aside if they stayed at the Shankly Hotel then they would have to pass through or by the entirety of your least favourite part of town if they went almost anywhere else (to eat or drink) at night time...
My own opinion is that parts of Cavern Walks are OK, and depending on how gregarious the OP and his wife are they might enjoy a lively drink in a couple of the places where people of all ages can be found.
You don't have to pass through Mathew Street to get to almost anywhere else in Liverpool from the Shankly Hotel. Blimey I sound like I am plugging the place now. Ha ha. Never stayed there, heard it is meant to be nice. The Hard Days Night is definitely nice. The Mathew Street area is carnage on a Saturday night, maybe they will like that maybe not. The White Star is a nice pub, so is the Grapes even though it smells like an open sewer. The Cavern Pub and The Cavern are going to be fine and worth a visit for a Beatles fan but mad busy with stags and hens on a Saturday night. Flanagans is O.K. Everywhere else around there is rough as a badgers arse. Inflatable cocks and people with learner plates on.