By far the greatest hazards in the London Overground, Underground, and I would suspect other cities' metro trains, are the nefarious activities of your fellow passengers. The fantastic visibility on S7/8 and Capitalstar stocks means anything untoward is seen by the entire train, and consequently suppressed to a large degree. Staff and Police can easily patrol and observe, and in turn be a visible presence on, the entire train.
The overall ambience of the train is one of openness and personal safety, and this contributes in no small degree to the popularity of the services right up to the close- this popularity also adds to the safe ambience, in a virtuous circle.
Revisting for example the D78, it feels positively claustrophobic in comparison. There's no going back, it would seem as retrograde as reintroducing compartment stock.
The practicalities such as additional standing space are minor in comparison. Accident safety is probably at least as good as anything else. In a full train you'll end in a heap of squashy individuals. Less full, you'll slide along the floor, eventually bumping into a partition, bulkhead or grab pole.
A picture, as they say...
Unit 378007 interior2 [CC BY-SA 3.0 (
http://creativecommons.org/licenses/by-sa/3.0) or GFDL (
http://www.gnu.org/copyleft/fdl.html)], by Sunil060902 (Own work), from Wikimedia Commons
LUL-S-Stock-special-needs-car [Public domain], by Spsmiler (Own work), from Wikimedia Commons
D78 DM INTERIOR District line [Public domain], by Peter Skuce (Own work), from Wikimedia Commons