The closure of the Woodhead route has always struck me as the biggest railway blunder in my life. I often think long and hard about it.
I think we would have lost the Worsborough Branch and Wath Yard with the demise of the coal industry. But the Manchester and Sheffield fast main line, lost to passengers and freight! The sheer barminess of its loss is something I ponder nearly every day.
Of course, the equipment was becoming life expired, but conversion to 25 kv AC would have been easy. I am very grateful to a correspondent called "Greybeard33" in a thread (I think in this subforum) on Class 76 pantograph height, for his revelation on 2 February 2021 that the cost of conversion of Manchester - Glossop / Hadfield was vastly lower in Greater Manchester Council's estimate than BR's.
I think the basic reason for the loss of the route was simply the geography of Sheffield. Rationalisation or concentration of traffic in city centre stations was not much on the agenda in the earlier BR era (pre-1960). It certainly was in the later one. It made sense to concentrate Sheffield passenger services on Midland. But I think it would have been extremely difficult, destructive and expensive to have built a steeply graded route from the Wicker Arches directly down into Sheffield Midland.
If, following a hypothetical but never happened conversion to 25 kv AC, with the new knitting extended down into Sheffield Midland from Nunnery Junction, the hourly (or probably by now, more frequent) expresses had been EMUs rather than loco-hauled, say using modern fast EMUs such as 350s in 4 or 8 car formations, the time from Manchester (London Road / Piccadilly) to Sheffield Midland would have been faster via Woodhead, even with a reversal at Nunnery Junction and the driver having to walk beside rather than through the train if crowded, than via the Hope Valley. I think this would be so whether the Hope Valley journey were via Romiley or via Stockport Edgeley.
Although, of course, serving the latter via the new LNWR to Midland connection at Hazel Grove has brought many benefits for Stockport passengers.