Pairing by use use is great when you have little interaction between fasts & slows and services on one tend to have a different destination to the other.
In your example it was great for the MML for most of it's history, but it's pretty lousy now with GTRs running an intense service, weaving from slows to fasts and back again, with every weave crossing something coming in the opposite direction, and given the frequency they almost always are timed to cross right behind something, or fairly close in front, so that just a small delay usually causes a knock on. Even the turnbacks at St Albans and Luton offer little relief these days as something's usually right behind a terminator.
About the only benefit now is that it's easier to get out of the freight terminals at Radlett, Luton, Limbury Road and Elstow, but I'm no longer convinced it's worth the trade off for a few freight conflicts compared with heaven knows how many passenger ones (and the freights still conflict with two lines instead of 3 or 4). The most difficult would be Radlett, which is perhaps close enough to run round facilities on the Hendons near West Hampstead to make a southbound departure line at Radlett the best option.
The MML really is hamstrung now by the combination of the pairing of lines and the combination of slow, semi fast, fast and express services, many of which weave across to get around the others or out of their way, and it's a bit of a nightmare for regular delays happening seemingly out of nothing, but I can't really see things changing.