Whilst I can't comment on specifics re sub stations, there were problems shortly after the Desiro fleet was introduced (because, I believe of the increased amount of on train equipment which is continually live) which resulted in the power supply being insufficient for the planned TT/formations at certain locations. This resulted in some services having to be driven in series IIRC until upgrades could be made. It is noticeable how most feeds to the third rail are now double cored (two cables) as opposed to the single cable that was sufficient in slam door days.
Relevant to the discussion about TPH along the Windsor/Reading route(s), I have no idea, but these newer trains are far more juice hungry than their old predecessors.