See it relatively often down my way.
The Scunthorpe to Eastleigh rail train operated by GBRf often has a second loco dead in train.
The longer DB stone trains are operated by two 66s in multi - they change where they operate to and from, but there was a Tytherington to Appleford flow for a while.
Freightliner sometimes have locos (66s or 70s) dead in train in the container trains from the North to Southampton.
I've also seen DB top and tailing the Southampton to Masborough container train with 66s. The rear 66 is then taken off at Didcot when the train passes through Didcot Yard - I think they do it to get the 66 from the Cowley car train back to Didcot, presumably there being no return trip of car carriers on those occasions.
The Mendip stone trains can also have locos dead in train to get them back to Merehead or Whatley - I've seen one with 59001, 59101 and 59201 on the front, for example.
Also the Hinksey to Easleigh engineering trains run by Colas can have a second loco dead in train, sometimes even a DB loco.
A couple of years ago now the Northolt to Severnside bin liner was run by DB with top and tail 66s - not sure why, it's back to a single loco now.