Some unlikely but marginally possible ideas:
(a) One possibility I can see would be a hypothetical banning, on safety or pollution grounds, of diesel engines under passenger carriages
If it occurred it would then require diesel engines either to be banned entirely or moved into a non passenger carriage which might end up as a locomotive simply as a convenience.
(b) Equally banning of batteries under passenger carriages, probably for the fire risk, which is more plausible.
(c) Diesel engines might also be banned from being used in the middle of trains, on grounds of pollution, at enclosed stations (like Birmingham New Street) which could perhaps see some move towards a single engine outside the over-roofs.
(d) I could also imagine a hydrogen powered train where the regulations prohibited passengers in the same vehicle as the hydrogen tank. (Not currently required AFAIK in any actual hydrogen train)
(e) One further thought is that at some future point diesel engines may simply not be available in a size that fits under a multiple unit and would have to be put into a locomotive unit. (Although you might as well just stick one in an end carriage on a multiple unit)
Essentially I see this as either regulatory or practical problems.
Whether or not any of these would also remove traction motors from the carriages (which would probably still be a multiple unit) is unknown and most of these are rather improbable.
Alternatively I could see a future setup where every carriage is an individual unit and they get grouped together for different runs rather than being a single multiple unit train.
Think in this case, an intercity train made up of 9 electric single car units combined together (one with a pantograph) and a through power bus, perhaps with a self-powered generator (locomotive) attached on the end to provide power on non-electrified lines. It's not exactly hauled coaching stock, but it's getting quite close.