I doubt it. But Whiston, Rainhill, St Helens Jn, Lea Green, Earlestown and Newton would justify 2 tph (at least) to Liverpool - these stations are no different in their hinterland to any of the rest of Merseyrail. This is going to be hard to do without Northern Powerhouse Rail taking the fast services off the route, though.
Hard is relative here. The December 2017 timetable delivered evenly spaced 2tph Monday - Saturday to the stations between Huyton and Earlestown, plus a third at St Helens Junction, without any performance or resourcing difficulties.
There's no technical reason why that's not possible in the December 2022 timetable. It is only the political imperatives that have put priority on other service groups, to the detriment of the Merseyrail 'City Line' group, in addition to standard British government underfunding of public services.
Heavy rail is a waste of time if it only runs hourly in urban areas. People won't use it in commercially viable numbers for trips to Liverpool city centre at such a low frequency, so it will only decay further. If there's no money for, at minimum, a half-hourly service from Whiston and Rainhill it would be better to mothball the stations and withdraw the stopping service completely. The money saved would pay for better bus services, or a tram line in a few years. The current situation is simply one of dishonesty about the basic facts.
Frodsham and Helsby aren't huge. Ellesmere Port has a frequent service via the Wirral.
2tph is likely to Liverpool is still likely to be delivered eventually from Helsby and Frodsham because it's actually being paid for by the Welsh Government. Obviously they will be via Runcorn, not Runcorn East, as you say.