I’ve alway’s had a fascination for Soviet and Russian aircraft, although I doubt we’ll see another An-225 fly again. It was a one off.
Indeed, there's absolutely no viable business case for building a new one. It only marginally made money for Antonov when someone else (ie the USSR) had paid all the design and build costs for it.
The reality is that there's nothing that it can move that can't go by 124 or sea if too large. It never moved anything time-critical.
That's before we get to the issue that noone is going to build a new aircraft using six feeble, ancient and inefficient Progress engines (the six on the 225 produced only 50% of the power that the 4 RR engines on an A380 produce and are a nearly 50yr old design), which means a wing and complete avionics redesign. Given that a production line 747F off the shelf cost about $400mn at the turn of the year, a single 'new' 225 would be north of $1bn easily.
Antonov is barely flying anything at the moment, it averages one or two flights a week and there's no way they can afford it. The Ukrainian state will have far more important things to spend that kind of money on post conflict and notably has declined to give any money to Antonov to assist. Wonderful piece of engineering that it was there was never a 'need’ for it post Buran, ie it couldn't do anything that couldn't be done a different way. It was a 'nice to have' because someone else had paid for it to be designed and built.