They are a good and efficient engine in the right environment. They are suited to low speed city work where there is limited hills.
They are not suitable to high speed intercity running in hilly terrain
Despite the likes of Volvo, Daimler & Cummins offering relatively small 4-cylinder units, particularly when they're tuned with high horsepower outputs relative to their size, you most likely would run into durability issues if used in particularly challenging scenarios where the engines are continually stressed.
With a Volvo D5K engine with 240hp versus the D8K which can be had with 280hp, only 40hp more, it’s likely the smaller unit has to work a little harder overall to achieve its output.
Where diesel vehicles are concerned at sustained higher speeds or where the route has continual hill climbs it should be preferable that you choose a vehicle with a larger unit with more torque, such as a Scania N250/280UD chassis with the 9ltr 5-cylinder unit. Scania purposely fit these with longer 5.13 rear differentials for sustained higher speed routes; this approach keeps engine rpm around 1500rpm@90kph(56mph).
The Volvo B5TL & B8L tri-axle are fitted a standard with a 6.20 rear differential, meaning you’d be at around 2000rpm at only 80kph(50mph) on high speed work.
For comparison's sake, an ADL Enviro 400MMC is generally fitted as standard with a 5.74 rear differential and Voith gearbox, another configuration that isn’t particularly suitable for high speed or work where there is continued stress on the engine. Even at 50mph you're still talking 1800rpm at a cruise; with a ZF Ecolife it would drop to around 1550rpm.