Managed to ride a few 397's recently at the Northern end of the route to compare with 390's.
From a performance point of view - what I can see is that the Pendolino's are barely any slower over the first few miles - maybe 10 seconds maximum in boost mode. Then their ability to run at enhanced speeds 15-20 mph over the non tilt rolling stock yields as much as a full minute advantage from Penrith to Carlisle for example and that is only 18 miles or so, with probably only 12 to 14 miles running at enhanced speeds once you take out the acceleration and braking zones.
I was talking to a Class 397 driver who claims to have test driven the 397's at 125mph and he claims that was done largely over the straighter sections of route. it is understood that Network Rail have to deliver some infrastructure enhancements to make 125mph possible on a day to day basis - though it wasn't clear what that would be - most probably some track realignment and increasd cant. Not sure if signal re-siting is needed as the 397's probably have brakes as good as the Pendolino's.
The current WTT is interesting though as the sectional running times are 4.5 mins slower for 397s than Pendolinos between Preston and Carlisle, yet the overall running time including station dwells is exactly the same over that stretch for both trains - 1 hour 18 mins. So Pendolino's are being assigned longer dwell times and station stops -probably for pathing purposes - remembering there are slower services using the line such as Northerns's services to Windermere and Barrow using 100mph stock that share the two-track WCML from Preston Northbound.
in that case- the extra performance seems wasted! But the WCML is clearly a far busier route than it was in 2004 when Pendolino's were being introduced.