Traffic density is always a constraint on maximum speeds where a line has a mix of fasts and intermediate services, however, the Brighton main line is four tracked to beyond where the metro services terminate, and with some careful fighting of fasts and inters, and using 387's* instead of just 377s, there could be a substantial speeding up of many of the longer journeys.
Similarly, on the SWML, the speed on the fasts from west of Wimbledon to Worting junction largely wouldn't get bogged down by the slows and most inters as each branch off the main line is grade separated. Thus the 450s* and 444s* could have the 350 motor overspeed modification to make 110mph available.
* Even if such changes were to happen, it is likely that the current stock would be replaced with contemporary EMUS a la class 730/2 Aventras as aquired for LNR services on the WCML