Nestlé: Lots of ethical concerns about them that others have mentioned in this thread. Luckily, it's usually quite easy to avoid products made by them, though the one product I find really hard to get hold of that isn't made by Nestlé is condensed milk.
Wetherspoons: Spoons is decent if you want somewhere familiar and cheap food & booze. I'm not a huge fan of how you have to go on a mission to find the toilets in every single one, but that's a limitation with the buildings they're in. I think the way Tim Martin's forced his political ideology onto his pubs (including allegedly sending people out from head office to ensure the Brexit propaganda is properly displayed) is pretty poor, though given I'm a Remainer, that's not much of a shock. What thoroughly annoyed me was his conduct at the start of lockdown, basically coming across as not really caring much about the welfare of his colleagues. Now, I'm taking the stance that I won't go to a Wetherspoons unless I'm desperate and haven't got much time to find anywhere else to eat/drink. There are plenty of other pubs where I'd rather spend my money, such as the two by Congleton station
Sports Direct: I'm trying to avoid swearing here, but Mike Ashley is just a despicable person who has no concern for his employees. Their footwear selection is decent, but that's not enough to make me want to go there. I'd much rather go somewhere like JD Sports for trainers these days, and I'm lucky that there's one of them in Hanley. Bit of a trek for me, but it's worth it.
Ryanair: They're cheap, and for good reason. I don't like the garish interiors of their planes (might be sensory-related due to my autism or something - I dunno). The constant announcements irritate me. The on-time fanfare is just pointless. Michael O'Leary's ideas for making more money are just nonsensical, though I'll concede they make for interesting PR. Oh, and I'm still not over that really rough landing I had when flying from Manchester to Eindhoven in July 2015. I've NEVER had a landing that bad before or since - it was like a kangaroo bouncing down the runway. I only go for Ryanair if there's no other option, which isn't usually the case. When it comes to budget airlines, I much prefer easyJet. Never had a bad experience with them.