If you happen to work somewhere in the Holborn area served by the X68 and used to take a train to London Bridge, then a 521 (formerly branded very successfully as a Red Arrow) from its bus station for the rest of the journey, you are now stuffed. The 521 has gone, and the replacement for that part of the route is the 133 being diverted to Smithfield i.e. well short of Holborn. Change to another route there? You used to have the 8,25 and 242. now down to the 8 and even that at a reduced frequency. Yes, you can change to a S.E. train to Waterloo from London Bridge, but I keep reading on the forum how much of a hassle that can be these days. TfL buses are in the biggest mess they ever have been, and it's not all down to money.
P.S. Before I get corrected, yes, the 133 does meet up with the other 'replacement' for the 521 at Smithfield ( the 59), but it's all discouraging and unnecessary.