Again, it varies by driver. A few will drive in boost mode all the time but I personally just leave it on the default setting which is eco mode. You can change to boost mode using the TMS. Even in eco mode, there is usually enough time/padding to be on time if not a few minutes early assuming obviously you don’t encounter any delays or cautionary aspects.
The only time usually I’ll have boost mode on is either when there is a traction motor isolated or locked (in which case boost mode is put on by default) or when relieving a driver at Preston, if it’s already put in boost mode I probably won’t bother changing it back to eco mode. Also, I might put it on when train is delayed by more than a few minutes.
On top of my head, there is no difference up to 50mph and then beyond 50mph, in eco mode only 85% of the traction power is used.
Reminds me actually, I want to try timing 0-125mph with and without boost mode and 221s.