To take the question at face value - yes this does happen.
However (and there are some huge caveats)...
As others have pointed out, this is entirely dependent on overtime and generally requires working 12-13 days out of 14, moving from earlies to nights and back again repeatedly over that period, and leaving very little time to see family or having anything of a life.
To which extent, it rather begs the question of what the point is - especially if there's little opportunity to enjoy your income (of course, some people have exceptional circumstances such as supporting relatives etc - in my experience, where colleagues are earning such a salary it tends to be more out of necessity than by choice - eg: going through a messy divorce/supporting ill family members etc).
The next caveat here is that such an income is entirely dependent on a rest day working agreement being in place. To that end, you could go from earning a pro-rata £100k+ salary one month, to £55k the next. Safe to say, that hurts both mood and pockets - and with industrial relations as they are, its happened at a fair few places.
Finally, its worth pointing out that whilst the salary can be very high, train drivers occupy a relatively unique position, in so far as a reasonably small number of errors could cost them their jobs. Unlike many similar roles, you're alone in the cab and there's very little to act as a check or balance on decision making - where in other roles there may be additional people to challenge decisions etc.