Reading between the lines, it looks like some of the answers relating to baking distances have been from passenger drivers (apologies if I've got it wrong chaps

) but when it comes to the braking of heavy freights it can be a very different ball game.... you can have the same loco and set of wagons all week but the braking characteristics can still feel different each time you apply the auto brake, even if you do so at the same 'mark' on each successive day along the same route. Empty wagons will be lighter of course, but the aerodynamics / turbulance they cause in windy conditions can slow you down by a surprising amount (even more so if you're on a rising gradient) which means you 'have a bit in hand' and don't need to apply the brake as much, or you can leave the initial application till you're a bit further on.
Sorry to veer of topic a bit, but all these factors are bound up together with our route knowledge, just as much as the speeds, junctions, stations etc are....