I'd be interested in your experience of this trip, whichever options you use.
I'd been planning to do a London-Lisbon journey (sometime post-pandemic) in 24 hours - morning Eurostar to Paris, TGV to Hendaye/Irun, sleeper to Lisbon. Efficient, civilised, and just 2 changes.
However, with the sleeper to Lisbon not returning, it sounds like what might have been possible in 24 hours can now barely be done easily and reliably by rail in 48! If it's that much faff, then I might never make my planned Lisbon trip at all.