I've not managed to go west of Maidenhead on a 387 yet, but the benefits of faster acceleration and less noise are the same. 387s have much faster acceleration than 165/166 DMUs. On leaving Slough they can already be at 90mph before passing Langley. In comparison, a 165/166 manages 80-85 on the longer distance between Maidenhead and Twyford before they have to slow down for the station. And for me the 165s/166s always seem to feel like they're going slower than they actually are.
For noise, the 165/166 units are louder when sat above the engine when compared to sitting over the motors on a 387. The 166s appear to have better sound insulation as their engines always seem quieter inside than 165s (but the same on the outside). Ok the 387s make annoying noises of their own (buzz from the transformer and the loud bangs from the circuit breaker), but most people would probably find that better than the engines running underneath. I also find that 387s seem slightly less insulated from rail noise over points compared to 165/166s.
As a DMU fan (

) I will miss the 165s, 166s and also the 180s, but there is no doubt that for the normal passenger a 387 is a far better travelling environment (both on board and while at the station due to the lack of fumes and noise).