The panel knowledge issue is immutable so this is all theoretical, but if that limitation did not exist, the following infrastructure would work:
Two permanent links from each signalling installation to regionally-separate interlocking centres — one primary, one secondary. If the primary goes down, the secondary takes over.
In said datacentres, panels for every area in the 'digital railway' run in permanent configurations, on a platform of commercial off-the-shelf VDI (virtual desktop infrastructure) servers, with standard enterprise redundancy. These panels would support route displays, CCTV video feeds, and any arbitrary number of voice lines — and even a GSM-R concentrator so that all of a signaller's needs are present and integrated. This entire installation would be exhaustively tested to current standards.
Entirely separate from this, operations centres would comprise of VDI clients to connect to the proven panels (plus each's associated facilities) — but these would only need to relay the already proven-and-tested information back and forth, with encryption and error checking built-in to the link.
At that point it might be cost-effective to maintain multiple operations centres, with some not normally used and just fulfilling the role of 'hot spare'. Large organisations already retain the services of companies specialising in providing and maintaining such office space for thousands of users, which will hopefully never be needed in earnest.