So, effectively, we're talking about tri-mode CL. 80x's? Third rail DC, OLHE AC, and diesel.
I agree its a very good idea to replace the 22x fleet with something more appropriate and longer, but in not sure you could get away with running third rail shoe equipment across the entire route.
Ideal to move away from diesel, I know, but as so many threads on here suggested, just not practical at this time (next 10 years) as the electric infills required just isn't there yet.
A good compromise though would be to run a bi-mode capable of 125mph on diesel on the GWML and the max line speed on the SWML (100mph? 110?) running on the overheads where possible.
I can't help but think though there would be an issue with different interferences between the GWML and the ECML with any 80x unit? Or were they the same interface issues present on both introductions doth the same solution?
But even that would be solvable, maybe, by only running on overheads on the ECML which is currently vastly more expansive than the GWML (reading - Didcot / Bristol Parkway (one hopes eventually Temple Meads) / Westerleigh Jn).