The 350s, 450s and 444s are some of the most reliable trains in the UK. Far more so than the equivalent Bombardier products.
The 350s 450s and 444s are all Siemens maintained so contractually and financially it makes sense for Siemens to minimise in service failures which they get penalised for. The Bombardier 357s, 375s, 376s, 377s, 379s and 387 are all TOC maintained and the TOC strike different balance and optimisation in terms of in increased maintenance cost vs in service failure costs (different to Siemens SWT/LM). Ramgate usually get circa 50k Miles per Technical Incident out of the SE units for example (as do the other good depots) but Bedford units were/are the worst by a country mile.
Hence you are effectively comparing Apple and Oranges or rather maintenance spend rather than the units themselves.
It is worth noting that Electrostars have far more electrical and electronic systems than Desiros so there is potentially more to go wrong. Desiro City is much more similar to electrostar with more electrical and electronic systems hence more and different things to go wrong and the steep learning curve Siemens are currently facing. Bombardier have had 15 years of learning with electostars to build on including the new train management (computer) system (TMS) that Aventra uses already having been fitted in the 379s, 387s and 377/6 &/7s. Siemens have had comparatively little learning time and experience on the 380s as their stepping stone and this is coming home to roost.
The big issue for Siemens is with the software which was outsourced (by Rail aka "Mobility") to a different division in Siemens and they are going from zero whereas Bombardier have had the 25+ years since the first iteration of the system was used on DB electric locomotives just after German reunification.
Siemens also spent lots of time complaining that the reality on NR was different to the test track and documentation not being detailed enough so their assumptions weren't always correct (NR 's point was probably that Bombardier just got on with it and made things work).